Hyaluronic acid is a natural non-sulfated polysaccharide of the glycosaminoglycan family of the extracellular matrix of connective tissue, synovial fluid and other tissues. 1,2 HA synthesis takes place in the cell membranes of most cells in the body and is then secreted into the extracellular space. HA also produced by fibroblasts in the presence of endotoxins. It is a key element in the wound healing process in calcified and non-calcified tissues. HA preparations used as fillers have been manufactured from bacterial or animal sources and their clinical effect generally lasts 6 to 12 months. HYADENT BG is a new biodegradable transparent hyaluronic acid gel of non-animal origin.1Say no to plagiarism. Get a tailor-made essay on “Why violent video games should not be banned”? Get the original essay Many in vitro and animal studies have reported encouraging results with HA, particularly with its positive effects on fibroblasts, bone regeneration and wound healing.3,4 HA acts as an anti-inflammatory5,6 and as a possible treatment option in osteoarthritis7 and as a soft tissue filler.8 In dentistry, HA has been shown to a positive effect on plaque-induced gingivitis with respect to plaque reduction and sulcus bleeding of patients.9,10 Only in a few studies has HA been applied as an adjunct to SRP in the non-surgical treatment of periodontitis. Johannsen et al.11 showed that after subgingival application of 0.8% HA gel immediately after SRP and 7 days later, bleeding on probing (BOP) and probing depth (PD) were significantly reduced . However, Xu Y et al.12 reported no influence of 0.2% HA gel application after SRP on clinical parameters after 6 and 12 weeks in patients with chronic periodontitis. Topically applied high molecular weight HyA has also been shown to stimulate differentiation and migration of mesenchymal and muscle cells in vivo.13 A recent clinical study14 showed that osteoconduction is more effective in transplantation. autogenous bone mixed with HA than in an autogenous bone graft alone. A Medline search including the keywords “periodontitis”, “healing of extraction sockets” and “hyaluronic acid” returned insufficient results. Keep in mind: this is just a sample. Get a personalized article from our expert writers now. Get personalized trialThe beneficial effect of a gel containing hyaluronan as an adjunct to non-surgical periodontal treatment in plaque-induced gingivitis is reported by clinical and paraclinical variables.15. However, the possible effect of HA in the treatment of periodontal diseases is inconclusive due to high variability in the available literature.16 Thus, the present study aimed to clinically and radiographically evaluate the healing of d extraction using HA and to evaluate the effect of HA with scaling and root planing in the periodontal treatment of patients with moderate to advanced chronic periodontitis and to compare it with scaling and root planing alone.