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  • Essay / Analysis of two articles: “Clearance of snescent glial cells” and “Zombie cells found in mouse brains before cognitive loss”

    The psychological news article I chose is called Cells zombies found in mouse brains before cognitive loss. loss. The author of this article is Sara Tiner of the Mayo Clinic. This article can be found on the Science Daily website, specifically available at https://www.sciencedaily.com/releases/2018/09/180919133024.htm (Tiner, 2018).Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get an original essayThe news source article discussed research on senescent cells. Senescent cells are unable to perform normal tasks in the brain compared to other cells, but they are nonetheless alive like any other. These cells are also identified as “zombie” cells. There are two types of senescent cells: microglia and astrocytes. Zombie cells are linked to many cognitive diseases that develop over time due to aging, such as atherosclerosis, osteoarthritis and neurodegenerative diseases – which would include Alzheimer's disease and Parkinson's disease for example. (Tiner, 2018). The study was carried out on mice. main test subjects. After eliminating senescent cells from aged mice with diagnosed cognitive impairments, they found that it helped extend a healthier lifespan. Researchers manipulated cognitive impairment by manipulating tau insults by breeding sticky spider-web neurons with specific genetic modifications that were introduced into mice. Once the tau proteins were successfully introduced into the mice, the senescent cells were completely eliminated. Once the senescent cells were removed, the mice were able to form memories and did not exhibit any sort of inflammation in their brains, even though tau proteins were inside them (Tiner, 2018). The scientific article in which the study was initially discussed is called Clearance. senescent glial cells prevents tau-dependent pathology and cognitive decline. The numerous researchers who conducted the study include Tyler J. Bussian, Asef Aziz, Charlton F. Meyer, Barbara L. Swenson, Jan M. van Deursen, and Darren J. Baker. This article can be consulted in the Nature International Journal of Science (Bussain, 2018). Senescence cells are caused by an irreversible involvement of the cell cycle, linked to a phenotype induced by intracellular and extracellular factors (Bussain, 2018). Scientists have not found any reason for the use of these specific cells in the brain. The cells inhibit the p16 protein, which is associated with diseases such as atherosclerosis, osteoarthritis, deterioration of other brain tissues as well as neurodegenerative diseases (Bussain, 2018). The study used a mouse model of tau-dependent neurogenerative diseases, where tau neurofibrillary function preserved normal cognitive function in mice. The mice were female mice aged three to six months while the male mice were ten months old (Bussian, 2018). Tau neurodegenerative diseases accumulate the two senescent cells, microglia and astrocytes. After removing neurofibrillary tau from the brain, the mice retained normal cognitive function. Senescent cells were eliminated using an INK-ATTAC transgenic that results in soluble and insoluble neurofibrillary deposition. Senescent cells play a role in tau-mediated diseases and.