Introduction: According to Marks (2002), chronic illnesses (CIs) are persistent illnesses that are rarely completely cured and do not resolve spontaneously. Some examples of chronic diseases (CDs) are asthma, severe allergies, seizures, diabetes mellitus, autoimmune diseases, high blood pressure, HIV/AIDS, sickle cell disease and cancer (Wikipedia, 2011) . Different chronic illnesses have different side effects; However, chronic diseases generally affect the adolescent population because they make them vulnerable to their environment and the demands of society. This article aims to address the quality of life of adolescents with chronic illnesses (CIA) as they live with their illnesses. Specifically, the discussion in this paper will focus on the following points: social isolation and the risk of poor education. Additionally, some interventions that can be used to help them overcome their challenges will be discussed in this article. Discussion: Adolescents with CD face challenges beyond fighting their disease. First, AICs are more vulnerable to other health problems because they are prone to social isolation. Social isolation can lead to other health problems like depression. According to Ursula Holley (2007), involuntary social isolation is a loneliness which is then described as "a painful, depressing state, a feeling of detachment that a person endures when there is a void in their life due to a life social or emotional dissatisfaction. » Social isolation is an unfathomable reality for people with chronic illnesses, as they are often limited by their illness and excluded from society. Social support networks (SSNs) are an important aspect of life, especially for CIAs, as their SSNs could help them alleviate their difficulties middle of paper...... CitedCredit Valley Hospital. (nd). Retrieved from http://www.cvh.on.ca/index.phpEngelke, MK, Guttu, M., Warren, MB (2008). Swanson, M., School nurse case management for children with chronic illnesses: Health, academic, and quality of life outcomes. Journal of School Nursing, 24(4), 205-14. Holley, U.A. (2007). Social isolation: a practical guide for nurses caring for clients with chronic illness. Rehabilitation Nursing, 32(2), 51-6. Kliebenstein, MA, Broome, ME, (2002). School reentry of children with a chronic illness: perceptions of parents and school staff. Pediatric Nursing, 26(6), 579-82.Lineham, K. (2010). Caring for young people with chronic illnesses: a case study. Pediatric Nursing, 22(2), 20-3. Marks, J. S. (2002). Chronic disease. In Encyclopedia of Public Health. Retrieved from the Gale Virtual Reference Library