Table of ContentsReactive Oxygen Species (ROS) and Testicular Damage: The Role of AntioxidantsFinal ThoughtsReferencesInfertility, a major health problem, affects approximately 10 to 15% of couples, and approximately 40% of infertility cases are attributed to the male partner. Nearly one in seven couples are infertile, meaning they have been unable to conceive a child even if they have had frequent, unprotected sex for a year or more. In almost half of these couples, male infertility plays at least a partial role. Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get the original essay Male infertility can be caused by low sperm production, abnormal sperm function, or blockages that prevent sperm delivery. Illnesses, injuries, chronic health conditions, lifestyle choices and other factors can contribute to male infertility. Infertility can result from disorders of the testicles themselves or from an abnormality affecting other hormonal systems, including the hypothalamus, pituitary gland, thyroid and adrenal glands. Low testosterone (male hypogonadism) and other hormonal problems have a number of possible underlying causes. Interference with any toxic exogenous substance at any level of the reproductive cycle can result in reproductive toxicity, making the reproductive cycle one of the most complex processes of biological functions. . Reproductive toxicity can be defined as the adverse effects of a chemical on any phase of the reproductive cycle, including impairment of reproductive function in males and females, as well as effects on the fetus or offspring. Various compounds have been shown to induce reproductive toxicity, which can subsequently confer infertility problems on an individual. One of the compounds reported to be toxic to the reproductive system is aspirin. Reactive oxygen species (ROS) and testicular damage: the role of antioxidants Reactive oxygen species (ROS) induced by testicular and sperm damage constitute an important pathology in 30 to 80% of cases. Maturing testicular germ cells and epididymal sperm are well endowed with an enzymatic and non-enzymatic salvage system that includes various enzymes, vitamins, and proteins to prevent oxidative stress-induced damage. Additionally, a number of nutritional antioxidants also provide protection against free radicals. These include certain micronutrients and non-nutritive components of fruits and vegetables. Non-nutritive components include polyphenols, including flavonoids and nonflavonoids. Many bioflavonoids are free radical scavengers, antioxidants, chelating agents, phytoestrogens, and modifiers of various enzymatic and biological functions. Quercetin is a flavonoid group form of polyphenols available in a number of fruits, vegetables, leaves and grains. Red onions and kale are common foods containing an abundance of quercetin. Quercetin is available as a natural product and dietary supplement used as an anti-inflammatory and antioxidant. Basic and clinical studies have reported the beneficial potentials of quercetin. Its potential benefits against cancer and various pathologies have been reported. Likewise, previous studies have shown that quercetin has,112