Having a feeling of pain and/or swollen joints, unusual hair loss, extreme fatigue, especially if you are a student), etc. uncomfortable for someone. Well, some people have to deal with these symptoms. These symptoms may be a sign of LUPUS; This disease is not biased because it can attack both women and men. A person suffering from unusual pains may complain at the moment, however, these small pains may be the small cause of another person or loved one who is suffering from these problems. Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get the Original Essay It also attacks healthy tissues which can cause several problems like joint inflammation, swelling, etc. The history of lupus is interesting because it has three periods: classical, neoclassical and modern. First in the classical period (1230-1856), although there was not much research on it at that time, lupus was marked as a skin disorder, but then it was made/ renamed Lupus. The world Lupus comes from the Latin word "Wolf", the reason it came from the word "wolf" was because at that time it looked like a facial lesion that resembled/reminiscent of a wolf bite. As there were many descriptive characteristics of lupus, many dermatologists were also involved, such as Cazenave, Thomas Bateman, Moriz Kaposia and many others, who participated in the investigation of lupus. Since there began to be more knowledge and also more patients with similar recognizable symptoms/scarf/lesion, discoid lupus was described in 1833 by Cazenave (also known as centrifugal erythema), and even more, information began to appear and describe like the butterfly. skin rash that was noted by Von Hebra in 1846. One of the first published illustrations of lupus (Lupus erythematosus) was discussed in Von Hebra's text Atlas of Skin Diseases in 1856. Then lupus came into the era neoclassical where the "true history" of lupus began in 1872, when a man named Kaposi described the disorder of systemic nature of lupus: "...experience has shown that lupus erythematosus...may be accompanied by changes much more serious pathological conditions and that even dangerous constitutional symptoms may be intimately associated with the process in question. and that death may result from conditions which must be considered as resulting from local disease. With his explanation/investigation, he proposed that there were two types of Lupus Erythematosus: the discoid form and the disseminated (systemic) form. Kaposi then talks about the symptoms that characterize this disease (but they will talk about them later in the symptoms section). ) Over time, a systemic form of lupus was established in 1904 by Osler in Baltimore and Jadassohn in Vienna. And now, as modern-day lupus, a 1948 investigation by Hargraves and colleagues observed that a person's bone marrow cell affected the wrong part of their body with the Lupus cell. .. is the result of... phagocytosis of free nuclear material with a resulting round vacuole containing this partially digested and lysed nuclear material...". The current discovery of Lupus has made it “easy” to diagnose a person with a much milder form of the disease. In the 1950s, two other markers were recognized as being familiar with lupus, the false-positive biological test for syphilis and the immunofluorescent test for antinuclear antibodies. " Dofun” at that time, if you worked in Baltimore, it showed that lupus was developed in 7% of 148 people with a false positive test for syphilis and 30% had symptoms consistent with collagen disease. Rather, an important fact about lupus is the most important one. the important thing is that it is not contagious, even through sexual contact, and you cannot catch it or give it to someone, nor touch it, from another, you cannot get it through any interaction . This is why, in history, it is difficult to know where it comes from, because no one knows. However, there is research that a dog can also have lupus, but the same thing I mentioned above about it not being contagious also applies here, you can't catching it from a dog, which again makes it difficult to follow its tracks. Nonetheless, this disease is not an epidemic or pandemic, but rather lupus is prevalent among women aged 15 to 44. Scientists believed that female hormones were the reason or one of the causes for the onset of lupus, and the reason they speculated was because it was a year old. that women can have babies. However, it is not as common to catch lupus at age 15, the only exception is if a woman with lupus has given birth, which does not mean the baby will have lupus, it can cause liver problems, of skin or heart to the baby, but if the mother is healthy or eats a healthy diet, the baby and the pregnancy itself can be healthy. But it is important that this disease is not gender biased, it attacks men equally, is not common in men but is more fatal/deadly/severe in men than in women. Thus, lupus can occur in anyone, regardless of gender, race, nationality or ethnic origin. According to an article titled “A Quick History of Lupus and What It Means for You” Lupus demographically: In the United States, between 20 and 150 women out of 100,000 develop lupus; Lupus is common among African Americans, but its prevalence among Africans is surprisingly lower than among African Americans. Additionally, in the "Lupus Foundation Of Northern California" goes a little further on how it affects African Americans and other women of color, they mention that it affects women of color are three times more likely than white women, and are additionally more common among Latino, Asian, and Native American women. Also how among African Americans, Latino Americans develop lupus at a younger age and have more symptoms at diagnosis. Even more, he explains that African Americans tend to have more seizures and strokes, and Latino/a tend to have more heart problems, as they mention on their website, they don't know why some people have more problems. with Lupus then other people or groups. Another article titled "Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus" talks/gives little information about the survival rate of lupus, which answers (not completely) the question of why minorities are the ones who suffer the most from this disease. They say the survival rate is less favorable among minorities, which they say may be linked to socioeconomic status rather than ethnicity, and social support is presented as a protective factor among the patients. As mentioned earlier, there is no exact model. transmission, nor contagiousness, and no one knows who it arrived through, so it is quite difficult to see how itentered a human's home. But what researchers know or believe/have an idea is how to “get” it. As stated in the previous paragraph, scientists believe that lupus develops due to internal and external factors such as hormones, genetics and environment. Before we begin on how lupus is "obtained", the information must come from the Lupus Foundation of America. So, let’s talk about hormones first; Hormones are the body's messengers and help regulate the body's functioning. Since lupus affects 9 out of 10 women, scientists and researchers have examined whether there is a relationship between estrogen and lupus. Since lupus affects both sexes, researchers look at men's and women's estrogen levels, which are much higher in women than in men. But what does estrogen have to do with lupus you may ask, it's because there is a pather that shows that when there are high amounts of estrogen, lupus is becoming more prevalent, which may be a small explanation for why it is prevalent among women due to when they are pregnant. or before menstrual periods, they produce it in large quantities. However, there are still some problems with this idea because it has not been proven between estrogen, or any other hormone, and lupus. Additionally, women with lupus taking estrogen while on birth control pills or after menopause showed no significant increase in the disease, leading to further research into the differences between men and women in terms of hormone levels, which may answer the question or lead to an idea of ​​why. women are more prevalent than men. Genetically, an important fact about lupus and genes is that no single gene has been proven to cause lupus. Researchers and scientists have discovered/identified that 50 genes are associated with lupus. These genes are more visible in a patient with lupus than in those without lupus, although these genes are not one hundred percent accurate, they must believe that they can contribute. However, genes are not a complete answer in this case, as evidence in twins raised in the same environment and with the same characteristics, only one can develop lupus while the other does not, but it is the case when there are two identical twins who If you have lupus, there may be an increasing chance that another twin will develop lupus. “30% chance for identical twins; 5 to 10% chance of having fraternal twins. Also, lupus does not need to be a family history, but it is another autoimmune disease in some family histories, and lupus, as it is not a group ethnically discriminatory, African American, Latino, Native American, Hawaiian, and Pacific Islander, are at greater risk of developing Lupus. Finally environmental, since genetics and hormones do not flourish, scientists are moving towards the thought that lupus may be an environmental agent, something that is chemical or encountered through walking or any other act that will trigger the disease, but it's still not certain if in fact this is the case (it's just a hypothesis). But the biggest evidence they have is ultraviolet light” (UVA and UVB); infections (including the effects of the Epstein-Barr virus) and exposure to silica dust in agricultural or industrial settings. The Lupus Foundation of America talks about other lupus triggers, "ultraviolet rays from the sun and/or fluorescent light bulbs, sulfonamides which make a person more sensitive to the sun,Sun sensitizing tetracyclines, penicillin or other antibiotics, infection. , colds or viral illnesses; Exhaustion, emotional stress » In the neoclassical period (1872-1948), Kaposi was the one who described the systemic nature of lupus, and further he described the signs/symptoms that characterized lupus, he cites as: “subcutaneous nodules, arthritis with synovial hypertrophy. of small and large joints, lymphadenopathy, fever, weight loss, anemia, central nervous system damage. And in the classical era (1230-1856), it was called the butterfly rash. Today, more and more symptoms have started to appear, but there has also been greater awareness. Currently, lupus has started to become more difficult to diagnose because it can easily be confused with other diseases or treated as a different disease, for this reason. earned his nickname “The Great Imitator”. An important point about lupus is that it does not have the same effect/symptom for every person, which means that each person can/will experience something different when having lupus. Some common signs listed by the Lupus Foundation of American are: "Red rash or color change on the face, often in the shape of a butterfly on the nose and cheeks, painful or swollen joints, unexplained fever, chest pain with deep breathing, swelling”. glands, Extreme fatigue (feeling tired all the time), Unusual hair loss (mainly on the scalp), Pale or purple fingers or toes from cold or stress, Sensitivity to the sun, Low blood counts and Depression, difficulty thinking , and/or memory problems. Other signs are mouth sores, unexplained seizures (seizures), "visions" (hallucinations), repeated miscarriages, and unexplained kidney problems. Another way to know the symptoms of lupus or to know if you have it is if you have some of this algorithm, these clinical characteristics and these laboratory tests. This algorithm is from “A Quick History of Lupus and What It Means for You,” “Here are some clinical signs of lupus: skin lesions, alopecia (a type of hair loss), mouth ulcers, synovitis (inflammation of the synovial membrane in joints ), Neurological symptoms (seizures, psychosis, etc.) Here are some laboratory and diagnostic findings that can be used to diagnose lupus: Blood tests (low white blood cell count, low platelet count, and low red blood cell count), Renal functional tests, kidney biopsy, urinalysis (looking for red blood cell casts) and immunological tests (think antibody tests like ANA, antiphospholipid, anti-Sm and anti-dsDNA) » However, this algorithm still follows since Different patients who People with lupus have had a different experience than others. Lupus has a “short” history of its treatment and how people made tents to deal with it. But it's important to know our daily important fact: no cure has yet been found for lupus, which makes it so dangerous, but that means it can be treated without being reduced/controlled. Most treatment information comes from the Lupus Foundation of America. In 1894, researcher Payne was the first to report the usefulness of quinine in the treatment of lupus. Time passes (4 years) and the use of salicylates in combination with quinnie has also become used and noticed as being beneficial. Later, in the 20th century, cortisone/corticosteroids were introduced for the treatment of lupus. Currently, corticosteroids constitute the.