I am a basic biochemist interested in what happens in cancer biology at the molecular level. I found it interesting that RNA biology and its underlying events play a crucial role in the above. My primary goal is to understand the fundamental mechanisms of protein synthesis and determine how these mechanisms contribute to both normal states and diseases, particularly celiac disease and cancer. The main mechanism for regulating protein synthesis occurs at the initiation stage. Initiating the translation of a messenger RNA requires recruiting the ribosome in the mRNA and positioning it at the initiator codon (AUG). The major mechanism of these processes is called the cap/scanning model in which the cap-binding protein binds to the 5' end of the mRNA, 7 methyl guanosine triphosphate, and recruits the translational machinery, including the 40S ribosome. . The ribosome, in turn, migrates or scans along the 5' leader until it encounters an AUG in an appropriate context. An alternative and less well understood mechanism is recruitment of the ribosome by the 5' leader. Say no to plagiarism. Get a tailor-made essay on “Why Violent Video Games Should Not Be Banned”? Get an original essay. These regions downstream of the cap structure are called internal ribosomal entry sites (IRES). IRESs have been best studied in a variety of clinical conditions and in a subset of viruses, including poliovirus and hepatitis C. To date, only a small percentage of eukaryotic mRNAs have been shown to contain an IRES and the The mechanism and function of these eukaryotic IRESs are not well studied. Understood. Conditions that inhibit or negatively regulate cap-dependent translation are proposed to maintain or positively regulate IRES-dependent translation. These same conditions contribute to cancer. My ultimate research goal is to identify IRESs in mRNAs that encode etiology-critical proteins that contribute to carcinogenesis (Aurora A Kinase). Additionally, I wish to examine the regulation (or misregulation) of the above IRESs in part by identifying intracellular signaling pathways that potentially lead to the post-translational modification of specific RNA-binding proteins in culture as well as 'to the creation of transgenic animals that can be well used for my research as well as for the future generation. Celiac disease (CD) is a chronic immune-mediated disease triggered by gluten ingestion in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred through the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase2. In India, when it comes to celiac disease, research is mainly focused on clinical aspects rather than pharmacological aspects. Many reviews have been published but most have reported clinical case studies. This is not a retrospective study published to date and the number of subjects involved or the underlying facts have not yet been brought to light for the benefit of the public..