The world is evolving with advances in technology. People in our society, including teenagers, adults and the elderly, are addicted to computers, television, cell phones, video games and cars. This dependence makes them sedentary. Going back to history, the human body is made for hunting, farming and housework, but advances in technology are making us sedentary. Sedentary lifestyle leads to increased chronic health conditions and all-cause mortality. The human body reacts to this change in nature by being less immune to many chronic diseases. Over the past decades, numerous studies, including observational and experimental, have examined and shown that physical activity significantly reduces morbidity and mortality. Moderate to vigorous physical activity helps improve a person's cardiorespiratory fitness, which helps reduce the risk of chronic diseases, including cardiovascular disease, hypertension, type 2 diabetes, and cancer. Many studies have also shown that physical activity or cardiorespiratory fitness reduces morbidity and mortality independent of body weight. India, known as the diabetes capital, has a large cohort of diabetic people with normal BMI. Low physical activity or low cardiorespiratory fitness could be the main reason for diabetes in this cohort. Physical activity prevents weight gain or helps control weight by increasing energy expenditure. Although most studies have shown that physical activity prevents morbidity and mortality independent of weight, the range of benefits varies across different groups stratified by age, sex, race, and BMI. Also, different dose of physics......middle of paper......in and elastin. Studies have shown that exercise prevents changes in collagen and elastin that lead to stiffness. Exercise also prevents the buildup of advanced glycation end products that increase with age and are known to cause stiffness. There is strong evidence that exercise causes collateral growths of arteries in the heart muscles. The mechanism behind this is attributed to stem cells similar to angiogenesis. Populations with atherosclerosis or other similar vessel damage may benefit from exercise because it results in increased collateral growths. The last, but not least, mechanism that helps in the prevention and cure of cardiovascular diseases is microRNAs. Different microRNAs have different mechanisms and consequences. MicroRNA 21 leads to increased fibrosis. MicroRNAs 29 help promote angiogenesis. MicroRNA 126 participates in improving ventricular compliance.