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Essay / Importance of Good Laboratory Practices (GLP)
Good laboratory practices (GLP) are a set of principles that guide how laboratory studies are planned, performed, monitored, recorded, reported and archived. This is different from laboratory safety standards (such as appropriate clothing). GLP helps ensure the credibility and traceability of submitted data, thereby addressing the problem of non-reproducibility in many biopharmaceutical experiments. GLP aims to minimize adverse drug reactions and improve safety profiles for human health and the environment. GLP also helps improve data reliability and accuracy through transparent and detailed documentation of laboratory work while assigning responsibilities to different stages of the experiment. Furthermore, the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) has mentioned GLP as a prerequisite for the successful international registration of pharmaceutical products. Say no to plagiarism. Get a tailor-made essay on “Why violent video games should not be banned”?Get an original essayTips for achieving GLPIImplement and/or follow standard operating procedures (SOPs) in the laboratoryIncluding SOPs relating to inspection, maintenance, calibration and testingHelps with SOPs to minimize inter-individual and inter-test variability, as well as facilitate reporting of complicated proceduresSeparation of different activitiesTo minimize disruptionLabel all reagents and solutions with their name(s) , opening date, storage conditions and expiry date Reagents should be used and obtained in accordance with the relevant SOPs Ensure that all animal studies are carried out in the appropriate species This facilitates appropriate dose selection Ensure that all techniques and instruments used are validated All data must be linked to their sources or samples Samples must be labeled with details of the patient/subject from whom the sample was obtained, as specified in SOP Document all results, not just those that favor the hypothesisEnsure all documents are readily available for reviewDocument all pre-defined inclusion and exclusion criteriaReport any excluded animals or subjectsAll analytical reports must be signed and dated by the relevant project managerReports must be retained for at least 5 yearsArchive systematically documents so that they are easily accessible at all timesBe familiar and up to date with all procedures (and their relevant SOPs) required of youIf necessary, ensure you have or obtain the certificate and qualifications Necessities required to perform the procedureAdhere to good laboratory practices and techniquesKnow the emergency SOPs and be prepared to perform them at any timeKnow the Safety Data Sheet (SDS) of the chemicals used in the experimentIf blood and/or or urine are used, keep in mind changes in blood/urine during storage and ensure that blood/urine is not stored longer than necessary. Ensure that changes during storage are accounted for or do not affect the results of the experiment..